Background and methods
Lactobacillus reuteri ATCC PTA 6475 (L. reuteri 6475) has been reported to increase bone mineral density in mice, but its effect on human bone is unknown.
The aim of this randomized, double-blind, placebo-controlled study was to investigate the effect of L. reuteri 6475 on bone loss in older women, 75-80 years old, with low bone mineral density. The study included 90 women who received L. reuteri 6475 (1×1010 CFU/day) or placebo for 12 months.
L. reuteri 6475 significantly reduced bone loss in older women with low bone mineral density.