In a newly presented systematic review the proof of effect on infantile colic was further strengthened for L. reuteri Protectis. The review is the eighth meta-analysis evaluating L. reuteri Protectis’ effect on infantile colic.

Prior to the new review seven meta-analyses, evaluating different probiotics as well as non-probiotic treatments, have come to the same conclusion; that L. reuteri Protectis is effective in reducing crying time in colicky infants, especially in breastfed and mixed fed infants.

In the new, eighth review, with four studies on L. reuteri Protectis included, the proof was further strengthened. It combined raw data from these trials (Individual Participant Data Meta-Analysis, IPDMA), a method that yields more reliable estimates of treatment effect compared to traditional meta-analyses based on published data only. The analysis was undertaken according to the methods recommended by Cochrane.

”A meta-analysis is considered the highest level of evidence of a health effect and now there are eight such meta-analyses with BioGaia ProTectis. While this clearly confirms BioGaia ProTectis as the number one treatment for infants with colic, it also reassures health care professionals around the world that they are suggesting an effective treatment when recommending BioGaia ProTectis drops to their patients”, says Axel Sjöblad, Managing Director, BioGaia.

The systematic review and meta-analysis was presented at the PAS (Pediatric Academic Societies) meeting in Baltimore, USA, 1 May 2016.

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BioGaia has published this information in accordance with the Swedish Securities Market Act. The information was issued for publication on 2 May 2016, 10:00 am CET.