Reduction of dysbiosis in children treated with proton pump inhibitors

Background and methods

Gastroesophageal reflux (GERD) is a condition when the gastric acid content flows back into the esophagus. Proton pump inhibitors (PPI) has become the first line therapy prescribed for children over one year with GERD. According to some research the use of PPI may be involved in the pathogenesis of small intestinal bacterial overgrowth (SIBO).
In this randomized, single-blind, placebo-controlled study 128 children with GERD were treated with PPI and L. reuteri Protectis (5 drops/day), or PPI and placebo, for 12 weeks. The prevalence of SIBO was determined by glucose hydrogen breath test before and after treatment. As reference, they were also compared to 120 healthy children.

Results

L. reuteri Protectis significantly reduced the prevalence of SIBO in children with GERD treated with PPI. In addition, L. reuteri Protectis also reduced gastrointestinal symptoms in children with SIBO.

Conclusion

L. reuteri Protectis as adjuvant to PPI treatment may reduce the prevalence of SIBO.

Can BioGaia’s products be stored in room temperature?

BioGaia Protectis drops comes in two different versions, we therefore recommend you to read what is stated on the package. The drops that can be stored in room temperature should be stored in a dry place, not above 25 °C / 77 °F.

Can BioGaia Protectis baby drops be stored in the freezer?

BioGaia Protectis bady drops should not be stored in the freezer. In the freezer the oil suspension will solidify, and the probiotic bacteria will be exposed to water. This process is severely shortening the shelf-life of the product.

Why does BioGaia Protectis drops come in a new delivery system?

In BioGaia we are constantly working on improving our products. The Easydropper is a new delivery system for probiotic products. It has an improved drop function which facilitates the administration of the product​ and less environmental impact compared to glass bottles.

What are the brownish dots that sometimes occure on the tablets?

The spots are not dangerous and the product can still be used. BioGaia tablets contains ascorbic acid, which is an antioxidant that contributes to the stability of the tablets. Over time the ascorbic acid oxidizes and the color becomes darker. This darkening is seen as small “spots” on the tablet.

What is Lactobacillus reuteri?

Lactobacillus reuteri is a probiotic strain that has co-evolved with humans since the beginning of time, and because of that it is adapted to its host. L. reuteri is among the first bacterial species to become naturally established in the normal microbiota of the newborn.

BioGaia’s probiotic products with L. reuteri are among the most scientifically well-documented probiotics in the world with regard to both efficacy and safety. To date the efficacy and safety of BioGaia’s different strains of L. reuteri have been documented in 184 clinical studies in 15,500 people of all ages. Results have been published in 159 papers in scientific journals (February 2018).

Read more about Lactobacillus reuteri.

BioGaia Protectis minipack

BioGaia Protectis minipack is a food supplement containing the patented lactic acid bacterium Lactobacillus reuteri Protectis (L. reuteri DSM 17938) that helps the good microorganisms restore a natural balance in the gut. BioGaia Protectis minipack is a probiotic powder that can be used in all cold foods and drinks. The convenient administration ensures that the whole family stays protected against infections regardless if they are sensitive to sweeteners or specific flavors, or if they have difficulties swallowing pills. The powder can either be sprinkled on foods, mixed into drinks or taken directly into the mouth.

Because L. reuteri Protectis naturally colonizes humans it has a strong adaptation to persist and interact with humans. L. reuteri Protectis has been tested in more than 130 clinical trials and proven both effective and safe for children.