Are there any side effects from taking BioGaia probiotics (Protectis/Gastrus/Prodentis)?

Since every gastrointestinal tract is unique some individuals might experience a temporary change in gut motility. BioGaia probiotics very rarely cause side effects in the amounts recommended for the products. Some individuals might experience gas (flatulence), but that generally disappears after a few days. No serious adverse effects have been observed in clinical trials up to the maximum tested dosage of 10 billion CFU per day.

BioGaia Osfortis

Probiotic capsules with vitamin D3

BioGaia Osfortis is a probiotic dietary supplement containing the patented lactic acid bacterium Lactobacillus reuteri Osfortis™ (Lactobacillus reuteri ATCC PTA 6475) and vitamin D3. Vitamin D contributes to the maintenance of normal bones. Because L. reuteri Osfortis naturally colonizes humans it has a strong adaptation to persist and interact with humans. L. reuteri Osfortis has been tested in clinical trials and proven effective and safe.


Lactobacillus reuteri reduces bone loss in older women with low bone mineral density

Background and methods

Lactobacillus reuteri ATCC PTA 6475 (L. reuteri 6475) has been reported to increase bone mineral density in mice, but its effect on human bone is unknown.

The aim of this randomized, double-blind, placebo-controlled study was to investigate the effect of L. reuteri 6475 on bone loss in older women, 75-80 years old, with low bone mineral density. The study included 90 women who received L. reuteri 6475 (1×1010 CFU/day) or placebo for 12 months.


L. reuteri 6475 significantly reduced bone loss in older women with low bone mineral density.