Are multi-strain products better than single-strain probiotic products?

Multi-strain products containing several strains in high doses do not necessarily have a better effect than a single-strain product. Important criteria when choosing a probiotic product are:

• The probiotic bacteria must be defined on strain level

• The probiotic product must have been tested in human clinical studies, with the same dose and with the same bacterial strain(s) as in the commercial product.

What is Lactobacillus reuteri?

Lactobacillus reuteri (L. reuteri) is a probiotic bacteria that has co-evolved with humans since the beginning of time, and because of that it is adapted to its host. L. reuteri is among the first bacterial species to naturally become established in the microbiota of the newborn. BioGaia probiotic products with L. reuteri are among the most scientifically well-documented probiotics in the world with regard to both efficacy and safety. To date 202 clinical studies with BioGaia’s L. reuteri-strains have been performed in more than 17,200 people of all ages. Positive results have been shown for several gastrointestinal disorders and oral health. Results have been published in 180 articles in scientific journals (February 2019).

Read more about Lactobacillus reuteri.

BioGaia Protectis tabs with vitamin D3+

BioGaia Protectis is a food supplement containing the patented lactic acid bacterium Lactobacillus reuteri Protectis®/™ (L. reuteri DSM 17938) that helps the good microorganisms keep a natural balance in the gut. Because L. reuteri Protectis naturally colonizes humans it has a strong adaptation to persist and interact with humans. L. reuteri Protectis has been tested in more than 130 clinical trials and proven safe for children and adults. Vitamin D contributes to the normal function of the immune system.

What are probiotics?

Probiotics are good bacteria that can be found in dietary supplements and sometimes in dairy products. Probiotics are defined as ”live microorganisms that, when administered in adequate amounts, confer a health benefit on the host.” (WHO/FAO 2002, Hill C et al. 2014). An important criterium for qualifying as a true probiotic is that health benefits have been proven in clinical studies. Furthermore, a probiotic product must contain the same bacterial strain(s) and the same dose that was used in the clinical studies.


Reduction in breath methane and relief of constipation


Detection of the gas methane (CH4) in exhaled breath is positively correlated to constipation, according to some research. Intestinal CH4 can slow intestinal transit time, and directly inhibit gut motility. Whether these alterations are a cause or a consequence of constipation is unknown.

This is an open trial, investigating the effect of L. reuteri Protectis DSM 17938 on the frequency of bowel movements and the level of methane in exhaled breath. The subjects were 20 constipated adults, all presenting with methane in their breath. Lactulose breath test was used at baseline and after 4 weeks of consumption of L. reuteri Protectis (2 tablets per day)

Positive detection of CH4 was defined as: production of > 5 ppm of CH4 at any time during four hours after oral ingestion of a 200-ml solution with 10 g of lactulose (= lactulose breath test).


Methane production in constipated adults can be reduced by daily ingestion of L. reuteri Protectis for four weeks. Reduced production of methane was associated with normalized number of weekly bowel movements. Ingestion of L. reuteri Protectis seems to modify the composition or the metabolism of methane producers of the gut microbiota.


Methane production in constipated adults can be reduced by daily ingestion of L. reuteri Protectis for four weeks