Inflammation is a major cause of bone loss. L. reuteri ATCC PTA 6475 has in preclinical trials been shown to affect immune cells that control bone remodelling. This leads to an increased activity of osteoblasts, that build bone, and a decreased activity of osteoclasts, that degrade bone, resulting in an increased bone density.2,3
1. Collins FL, Rios-Arce ND, Schepper JD, Jones AD, Schaefer L, Britton RA, McCabe LR, Parameswaran N. (2019) Beneficial effects of Lactobacillus reuteri 6475 on bone density in male mice is dependent on lymphocytes. Sci Rep. 9(1):14708. doi: 10.1038/s41598-019-51293-8.
2. Britton RA, Irwin R, Quach D, Schaefer L, Zhang J, Lee T, Parameswaran N, McCabe LR. (2014) Probiotic reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model. J Cell Physiol. 229:1822–1830.