This randomised, double-blind, and placebo-controlled study investigated the effects of the probiotic bacterium Lactobacillus reuteri on the levels of salivary mutans streptococci and lactobacilli in cleft lip/palate children.

The study product was an oil emulsion containing Lactobacillus reuteri DSM 17938 and Lactobacillus reuteri ATCC PTA 5289 (≥ 2×10^8 CFU/5 drops), or an equivalent placebo oil formulation. 19 operated cleft lip/palate children aged 4–12 years were included.

The experimental period consisted of four consecutive periods. During periods 2 and 4 (25 days each, respectively), the children were administered 5 drops per day of either of the study products in a crossover design. Periods 1 and 3 were washout periods. The counts of salivary mutans streptococci and lactobacilli were evaluated. There were no statistically significant (p>0.05) reductions of either salivary mutans streptococci or lactobacilli after 25 days of consumption of any of the drops.

Conclusions
The novel drop formulation with Lactobacillus reuteri DSM 17938 and ATCC PTA 5289 may not reduce the levels of salivary mutans streptococci and lactobacilli in cleft lip/palate children.

 

Reference

Cildir S, Sandalli N, Alp F, Caglar E. A novel delivery system of probiotic drop and its effect on dental caries risk factors in cleft lip/palate children. Cleft Palate Craniofac J. 2012;49:369-372. 

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