This was a prospective, randomised, double blind and placebo-controlled study that investigated the effect of Lactobacillus reuteri on the eradication of Helicobacter pylori.

Thirty patients were enrolled, aged 25–56, suffering from dyspepsia (indigestion) caused by a confirmed infection with Helicobacter pylori. 15 patients were given omeprazole (20 mg/day) plus Lactobacillus reuteri ATCC 55730 (10^8 CFU, twice daily) and 15 received omeprazole plus placebo, for 30 days. The extent of Helicobacter pylori infection was controlled four weeks after the end of the therapy. In 60% (9/15) of the patients supplemented with Lactobacillus reuteri, Helicobacter pylori was totally eradicated, while no eradication occurred in the group that received omeprazole plus placebo (p<0.0001).

saggioro_2005

Conclusion: From this study is seems that supplementation with the probiotic Lactobacillus reuteri in combination with omeprazole (PPI) has a beneficial effect on Helicobacter pylori infection in humans.

 

Reference

Saggioro A, Caroli M, Pasini M, Bortoluzzi F, Girardi L, Pilone G. Helicobacter pylori eradication with Lactobacillus reuteri. A double blind placebo-controlled study. Dig Liver Dis 2005;37(suppl 1): S88, abstr. PO1.49.

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