This was a prospective, randomised, double blind and placebo-controlled study that investigated the effect of Lactobacillus reuteri on the eradication of Helicobacter pylori.
Thirty patients were enrolled, aged 25–56, suffering from dyspepsia (indigestion) caused by a confirmed infection with Helicobacter pylori. 15 patients were given omeprazole (20 mg/day) plus Lactobacillus reuteri ATCC 55730 (10^8 CFU, twice daily) and 15 received omeprazole plus placebo, for 30 days. The extent of Helicobacter pylori infection was controlled four weeks after the end of the therapy. In 60% (9/15) of the patients supplemented with Lactobacillus reuteri, Helicobacter pylori was totally eradicated, while no eradication occurred in the group that received omeprazole plus placebo (p<0.0001).
Conclusion: From this study is seems that supplementation with the probiotic Lactobacillus reuteri in combination with omeprazole (PPI) has a beneficial effect on Helicobacter pylori infection in humans.