This was a prospective, randomised, double blind and placebo-controlled study that investigated the effect of Lactobacillus reuteri on the eradication of Helicobacter pylori.

Thirty patients were enrolled, aged 25–56, suffering from dyspepsia (indigestion) caused by a confirmed infection with Helicobacter pylori. 15 patients were given omeprazole (20 mg/day) plus Lactobacillus reuteri ATCC 55730 (10^8 CFU, twice daily) and 15 received omeprazole plus placebo, for 30 days. The extent of Helicobacter pylori infection was controlled four weeks after the end of the therapy. In 60% (9/15) of the patients supplemented with Lactobacillus reuteri, Helicobacter pylori was totally eradicated, while no eradication occurred in the group that received omeprazole plus placebo (p<0.0001).


Conclusion: From this study is seems that supplementation with the probiotic Lactobacillus reuteri in combination with omeprazole (PPI) has a beneficial effect on Helicobacter pylori infection in humans.



Saggioro A, Caroli M, Pasini M, Bortoluzzi F, Girardi L, Pilone G. Helicobacter pylori eradication with Lactobacillus reuteri. A double blind placebo-controlled study. Dig Liver Dis 2005;37(suppl 1): S88, abstr. PO1.49.

Crawling baby

For the avoidance of doubt, BioGaia’s products are food supplements, and the information on this part of the website should not be interpreted as our products are intended to diagnose, treat, cure or prevent any disease.

The information on this part of the website is intended only for health care and business professionals. If you are not a health care or business professional and would like to learn more about the indications BioGaia works with, please visit our Expertise pages.

Please read terms & conditions before accepting. By clicking on the button “I acknowledge and accept” you confirm that you are a healthcare or business professional and have read and understood this disclaimer including the terms and conditions.