Randomized, double-blind and placebo controlled trial of the effect of L. reuteri in children on the cytokine production in the lung in 4-10 year old children with atopic (AD) and non-allergic dermatitis. Study products were ingested for 8 weeks, with 26 in the L. reuteri group and 25 in the placebo group.
In AD patients only L. reuteri significantly increased the IFN-gamma production and decreased IL-4 levels in exhaled breath condensate. The quotient of the Th2/Th1 cytokines was thereby modified in a positive way. There were no changes in clinical scores of eczema.
Oral administration of a specific probiotic strain in patients with atopic dermatitis can modulate the cytokine pattern at a body site distant from the intestines.
Miniello VL, Brunetti L, Tesse R, Natile M, Armenio L, Francavilla R. Lactobacillus reuteri modulates cytokines production in exhaled breath condensate of children with atopic dermatitis. J Pediatr Gastroenterol Nutr 2010;50:573-576.