Open trial to evaluate if proton pump inhibitor pantoprazole (PPI) in combination with L. reuteri DSM 17938 may eradicate H. pylori infection in adults. Intervention was administered for 8 weeks + follow-up at 4-6 weeks thereafter. Twenty-two (22) subjects were included, given L. reuteri at the dose of 1×10^8 CFU/d plus 20 mg x 2 of pantoprazole/d.

L. reuteri plus PPI twice a day cured 13.6 % (3/22) of patients with H. pylori infection by intention-to-treat analysis and 14.2 % (3/21) by per protocol analysis. There was a significant reduction in urease activity, comparing baseline to 4–6 weeks post therapy.

Conclusion: L. reuteri may have a potential role in H. pylori eradication therapy if the cure rate can be improved by changes in dose, dosing interval, or duration of therapy.