Persistence of Lactobacillus reuteri in the human intestinal tract
This open trial investigated the colonisation and persistence of Lactobacillus reuteri DSM 17938 after daily or alternate day dosing.
Healthy adult volunteers ate pudding with Lactobacillus reuteri(10^9 CFU) daily (n = 9) or on alternate days (n = 9) during 7 days. Faecal samples were collected on dosing days and after dosing ended (day 13–15 and day 20–22), and analyzed for Lactobacillus reuteri.
The Lactobacillus reuteri count increased significantly in both groups during the week of ingestion and fell in both groups 1 week after dosing ended. Faecal levels on days 2–4 were of the same magnitude as on days 5–7 for both groups. Whether alternate day dosing had any effect on different parameters of presumptive clinical outcome measures was not studied.
Relevant faecal counts of Lactobacillus reuteri were reached already after 2–4 days of supplementation. Alternate day intake achieved a colonisation equivalent to daily intake. Once dosing stopped there was a rapid decline in faecal counts.