One of the most studied probiotics in the world

BioGaia’s probiotic products with L. reuteri are among the most scientifically well-documented probiotics in the world with regard to both efficacy and safety. To date the efficacy and safety of BioGaia’s different strains of L. reuteri have been documented in 224 clinical studies in around 18,000 people of all ages (May 2020). Studies have been performed on:

  • Infantile colic and digestive health in children
  • Antibiotic-associated diarrhoea (AAD)
  • Acute diarrhoea
  • Gingivitis (inflammation of the gums)
  • Periodontal disease
  • General health
  • Helicobacter pylori (the gastric ulcer bacterium)
  • Osteopenia

L. reuteri has shown result in 110 clinical studies in children, from newborns up to 18 years old, and 114 studies in adults. Probiotic strains that have been used in clinical trials are BioGaia Protectis (DSM 17938), BioGaia Gastrus (ATCC PTA 6475) and BioGaia Prodentis (ATCC PTA 52899. Results have been published in 207 papers in scientific journals (May 2020).

Clinical studies


Research on bacteria

Research on bacteria and their significance for our health has exploded in the past decade and is now one of the hottest research areas. At BioGaia, research on L. reuteri has been taking place for more than 30 years. A unique network of specialists at around 50 research institutes and clinics studies not only the effectiveness of L. reuteri for various indications but also how and why it works. Read more about our Research network

The importance of gut bacteria


Clinical trials supporting the use of BioGaia Probiotics ​

L. reuteri Protectis, Prodentis, and Gastrus

Clinical trials with BioGaias patented strains of L. reuteri

203 completed clinical trials in ​17,200 individuals​

140 randomised, double-blind / blind, placebo-controlled studies in 11,700 subjects​

63 open studies in 5,500 subjects​

67 studies in 0-3y in 8,200 subjects​


Our health areas

The human microbiota, i.e. microorganisms residing in the gastrointestinal tract, is believed to be established directly from birth and during the early years of life. Read more

Clinical studies

To date, 224 clinical studies using BioGaia’s human strains of L. reuteri have been performed on about 18,000 individuals of all ages. Results have been published in 180 articles in scientific journals (May 2020). Read more

What is L. reuteri?

Research has shown that L. reuteri is a species of bacteria that has developed a mutualistic relationship with its specific host over millions of years. Read more